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Screening of cervical carcinoma

Cancer occurs when cervical cells become abnormal and, over time, grow out of control. The cancer cells invade deeper into the cervical tissue. In advanced cases, cancer cells can spread to other organs of the body.

Most cases of cervical cancer are caused by infection with HPV. HPV is a virus that enters cells and can cause them to change. Some types of HPV have been linked to cervical cancer as well as cancer of the vulva, vagina, penis, anus, mouth, and throat. Types of HPV that may cause cancer are known as “high-risk types.”

HPV is passed from person to person during sexual activity. It is very common, and most people who are sexually active will get an HPV infection in their lifetime. HPV infection often causes no symptoms. Most HPV infections go away on their own. These short-term infections typically cause only mild changes in cervical cells. The cells go back to normal as the HPV infection clears. But in some women, HPV does not go away. If a high-risk type of HPV infection lasts for a long time, it can cause more severe changes in cervical cells. High-grade changes are more likely to lead to cancer.It usually takes 3–7 years for high-grade changes in cervical cells to become cancer. Cervical cancer screening may detect these changes before they become cancer. Women with low-grade changes can be tested more frequently to see if their cells go back to normal. Women with high-grade changes can get treatment to have the cells removed.

How is cervical cancer screening done?
Cervical cancer screening includes the Pap test and, for some women, an HPV test. Both tests use cells taken from the cervix. The screening process is simple and fast. Patient lie on an exam table and a speculum is used to open the vagina. The speculum gives a clear view.
Cells are removed from the cervix with a brush or other sampling instrument. The cells usually are put into a special liquid and sent to a laboratory for testing:
For a Pap test, the sample is examined to see if abnormal cells are present.
For an HPV test, the sample is tested for the presence of 13–14 of the most common high-risk HPV types.
ow often you should have cervical cancer screening and which tests you should have depend on your age and health history:

Women aged 21–29 years should have a Pap test alone every 3 years. HPV testing is not recommended.
Women aged 30–65 years should have a Pap test and an HPV test every 5 years (preferred). It also is acceptable to have a Pap test alone every 3 years.
Patient should stop having cervical cancer screening after age 65 years.
Patient do not have a history of moderate or severe abnormal cervical cells or cervical cancer, and
Patient have had either three negative Pap test results in a row or two negative co-test results in a row within the past 10 years, with the most recent test performed within the past 5 years.
have had a hysterectomy, you still may need screening. The decision is based on whether your cervix was removed, why the hysterectomy was needed, and whether you have a history of moderate or severe cervical cell changes or cervical cancer. Even if When cervix is removed at the time of hysterectomy, cervical cells can still be present at the top of the vagina. If you have a history of cervical cancer or cervical cell changes, patient should continue to have screening for 20 years after the time of your surgery.

Are there any women who should not follow routine cervical cancer screening guidelines?
Women who have a history of cervical cancer, are infected with human immunodeficiency virus, have a weakened immune system, or who were exposed to diethylstilbestrol before birth may require more frequent screening and should not follow these routine guidelines.

Having an HPV vaccination does not change screening recommendations. An abnormal result does not mean that you have cancer. Remember that cervical cell changes often go back to normal on their own.
If patient have an abnormal screening test result, additional testing is needed to find out whether high-grade changes or cancer actually are present. Sometimes, only repeat testing is needed. In other cases, colposcopy and cervical biopsy may be recommended to find out how severe the changes really are. If results of follow-up tests indicate high-grade changes, you may need treatment to remove the abnormal cells. You will need follow-up testing after treatment and will need to get regular cervical cancer screening after the follow-up is complete.
As with any lab test, cervical cancer screening results are not always accurate. Sometimes, the results show abnormal cells when the cells are normal. This is called a “false-positive” result. Cervical cancer screening also may not detect abnormal cells when they are present. This is called a “false-negative” result. To help prevent false-negative or false-positive results, Patient should avoid douching, sexual intercourse, and using vaginal medications or hygiene products for 2 days before your test.

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